DogsFlea and Tick PreventionPetProduct Comparison

Simparica vs. Simparica Trio: The Preferred Treatment for Your Dog

Simparica vs. Simparica Trio: The preferred treatment for your dog

Simparica and Simparica Trio are two of the most renowned products that eradicate fleas and ticks in dogs. There are numerous questions that surround these two products and many pet parents want to understand which of the two is a better option for their dogs.

Let’s take a closer look at both products to know further.

Understanding the Difference: Simparica vs. Simparica Trio

Both treatments are FDA-approved treatments for dogs that need to be offered once a month. These liver-flavored chewable treatments are manufactured by the same pharmaceutical company, Zoetis, and eradicate fleas and ticks in a matter of a few hours and also prevent Lyme disease. They continue to remain effective for 30 days.

Simparica is formulated using the active ingredient Sarolaner and Simparica Trio is made up of Sarolaner, Moxidectin, and Pyrantel. The treatments cure fleas of all stages and five types of ticks that are commonly found in the United States – the Gulf Coast tick, the lone star tick, the brown dog tick, the American dog tick, and the black-legged tick, a carrier of Lyme disease.


  • Simparica is an effective liver-flavored chewable treatment for the eradication of fleas and ticks.
  • It can be orally administered to dogs.
  • It remains active for one month.
  • It starts killing fleas within 3 hours and ticks within 8 hours.
  • The treatment is ideal for all breeds of dogs.

Simparica Trio

  • Simparica Trio is a highly advanced liver-flavored chewable for dogs and puppies.
  • It is an easy-to-feed monthly treatment that prevents heartworm disease and protects against ticks, fleas, roundworms, and hookworms.
  • The treatment kills fleas before they can lay eggs.
  • It is suitable for dogs over 8 weeks of age

Comparison between Simparica and Simparica Trio

The table below features a detailed comparison between Simparica and Simparica Trio.


1. Value: Simparica Trio

Both the treatments come in six weight brackets: 2.8 to 5.5 lbs, 5.6 to 11 lbs, 11.1 to 22 lbs, 22.1 to 44 lbs, 44.1 to 88 lbs, and 88.1 to 132 lbs with three options for the number of chewables to buy at a time: three, six and twelve.

When the same size and monthly package is taken into consideration, Simparica is less expensive. However, if a pet parent buys Simparica, he/she will also need to buy a separate monthly treatment for heartworm and intestinal parasites. Simparica Trio might look more expensive when compared with Simparica but the fact that it also protects against heartworms, roundworms, and hookworms makes it more value for money.

2. Killing Fleas: Simparica

Simparica Trio begins killing fleas within 4 hours of administration, whereas Simparica starts killing them within 3 hours.

3. Treating Ticks: Tie

Both Simparica and Simparica Trio start killing ticks within 8 hours of administration. A regular monthly administration of either of these treatments protects dogs from five types of ticks.

Also, Read- Is Climate Change Affecting Flea And Tick in Your Dogs?

Bottom Line

From the above comparison, it is evident that Simparica Trio, the advanced version of Simparica is way superior in features. When it comes to flea and tick treatment, both Simparica and Simparica Trio are equally effective. But when a dog is infested with worms, one has to opt for Simparica Trio.

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